Advanced Analytical and Separation Sciences
Valentia Analytical excels in separation technologies vital for the biopharmaceutical industry, featuring state-of-the-art chromatographic and capillary electrophoresis techniques. Our laboratory systems, equipped with Ultra-High Performance Liquid Chromatography (UHPLC) and High Performance Liquid Chromatography (HPLC), deliver superior resolution and adaptability. We further enhance our analyses with advanced detection modalities, including UV-Visible Spectroscopy, Fluorescence Detection, and Mass Spectrometry, ensuring precise molecular identification and quantification. Committed to analytical excellence, Valentia supports all stages of drug development and manufacturing, providing reliable, high-quality results that advance research and regulatory compliance.
Used for separating compounds based on hydrophobic interactions, reversed-phase chromatography is the most common chromatographic technique employed in the pharmaceutical industry. It is extensively utilized to monitor impurities, identify degradation products, and determine the purity of drug substances and products. This methodology is pivotal in ensuring the safety and efficacy of pharmaceuticals through rigorous quality control processes.
Reversed-Phase
Chromatography
(RP-HPLC)
Separates molecules based on differences in charge, employing a stationary phase that can be either acidic or basic, reflecting cation exchange chromatography or anion exchange chromatography. It is particularly effective for resolving charged variants of proteins, making it indispensable in the characterization and quality control of biopharmaceuticals where charge variations can significantly impact therapeutic performance
Cation/Anion Exchange Chromatography
(CEX/AEX)
Utilized for determining the molecular size and shape of compounds, crucial in analyzing protein aggregates, protein fragments, and polymers. This technique is key in the quality control of biologics where aggregation can affect efficacy and safety.
Size Exclusion
Chromatography
(SE-HPLC)
Targets specific molecules for separation based on a unique binding interaction with a particular ligand. This method is particularly useful in pre-harvest or harvest titer measurements.
Affinity Chromatography
Provides a reliable assessment of molecular weight and purity for protein samples. Samples may be analyzed under non-reduced or reduction conditions in confirming the integrity of monoclonal antibodies and other therapeutic proteins during drug development.
Capillary Electrophoresis Sodium Dodecyl Sulfate (CE-SDS)
Used for achieving high-resolution analysis of proteins based on their isoelectric points. This technique is critical in characterizing charge variants of biopharmaceuticals, ensuring product consistency and efficacy.